Although activating KRAS mutations occur frequently in cancer, targeting this oncogene has proved difficult. Three groups have now identified pathways that have not been previously linked to KRAS ...

Murine Kras-driven lung cancer models have confirmed the key requirements for RAF, PI3K and RAL-GEF in vivo. Co-opted pathways required by oncogenic KRAS in order to sustain lung tumorigenesis ...

But KRAS is no space station. It’s a lethal, misshapen protein that jumpstarts a pathway that drives almost a quarter of all cancers, and it has baffled scientists who have spent almost four ...

Background: “The KRAS pathway plays a crucial role in cell biology by regulating cell growth, proliferation, differentiation, and survival,” said Xie. “While KRAS signaling is tightly ...

“The KRAS pathway plays a crucial role in cell biology by regulating cell growth, proliferation, differentiation, and survival,” said Hao Xie, MD, PhD, senior author of the study and a medical ...

"The KRAS pathway plays a crucial role in cell biology by regulating cell growth, proliferation, differentiation, and survival," said Xie. "While KRAS signaling is tightly regulated in normal ...

When one of the proteins in the pathway is mutationally activated, it can drive tumor development and growth. RAS is the most frequently mutated oncogene in cancer, with KRAS mutations occurring ...

encoding the KRAS G12D neoantigen and cyclic GMP-AMP (cGAMP), a stimulator of the interferon genes (STING) pathway. This dual approach aims to activate type I interferon signaling, promoting ...

VS-7375, a potential best-in-class oral KRAS G12D (ON/OFF ... models corresponding with nearly complete shutdown of RAS/MAPK pathway signaling BOSTON, March 25, 2025--(BUSINESS WIRE)--Verastem ...