whose onset is correlated with repetitive microinjuries to the lung alveolar epithelium and abnormal alveolar wound repair. Although a high degree of mechanical stress (>20% linear strain) is thought ...

Design We developed a mouse model that closely resembles EoE by utilising oxazolone haptenation in mice with transgenic overexpression of an eosinophil poietic and survival factor (interleukin (IL)-5) ...

Mar. 3, 2025 — A new study sheds light on ventilator-induced lung injury, a complication that gained increased attention during the COVID-19 pandemic, which led to a surge in patients requiring ...

Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a form of acute-onset hypoxemic respiratory failure characterised by an acute, diffuse ...

Pulmonary fibrosis is an interstitial lung disease. Interstitial lung diseases are a group of conditions that cause inflammation and scarring around the tiny air sacs (alveoli) in the lungs. Inhaling ...

In animal models, inhibition of neutrophil chemokines or disruption of these chemokine gradients in the lung attenuates ALI. Molecules associated with enhanced wound closure, such as epithelial ...

The word "idiopathic" means it has no known cause. Scarring causes stiffness in the lungs and makes it difficult to breathe. Lung damage from IPF is irreversible and progressive, meaning it gets worse ...

Characteristic X-Ray Film of Stage I (A), Showing Bilateral Fine Pulmonary Granularity and Air Bronchogram, and Hyaline Membranes in the Alveoli ... of the respiratory epithelium or a relation ...

The epithelial–mesenchymal transition is the process by which polarised epithelial cells that are connected via adhesion lose their characteristics and acquire migratory and invasive properties ...

We aimed to better understand these mechanisms by using a functional 3D approach. Design Proliferation, mitosis and the expression of progenitor lineage markers were assessed in normal squamous ...