这篇综述聚焦葡萄膜炎中 Th17 细胞，探讨其在炎症和免疫调节中的双重作用及治疗策略。 ### 引言 在免疫介导的疾病领域，Th17 细胞作为白细胞介素 - 17（IL-17）产生的 CD4 + T 辅助细胞，因其独特的功能和复杂的调控机制备受关注。它由具有不同调节方式和功能的 ...

Ex vivo analysis showed that tumour-infiltrating IL-17+ cells mostly consist of CD4+ T helper 17 (Th17) cells with multifaceted properties. Indeed, owing to IL-17 secretion, CRC-derived Th17 triggered ...

Objective We aimed to investigate the role of GPR171 in modulating CD4 + T cell effector functions in IBD and evaluate its therapeutic potential. Conclusions GPR171 deficiency promotes Th17 cell ...

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, United States; Department of Microbiology, UMass Chan Medical School, United States; ...

As a crucial cellular process involved in degrading and recycling damaged organelles and proteins, autophagy-related (ATG) proteins mediated autophagy plays a significant role in various physiological ...

基因表达分析是研究的重要部分。RNA - seq 和基因集富集分析（GSEA）表明，低温下肾脏组织中与 FFA 代谢过程、线粒体相关的基因表达上调，尤其是参与 β - 氧化的基因，如 Plin5、Cpt1a、Slc27a1 和 Ppara 等。Western blot 分析显示，相应的蛋白 PPARα、FATP1、PLIN5 和 CPT1A ...