positively charged residues in an extracellular domain (S4) are important for channel gating. Sodium channels are important for generating electrical signals in neurons.

Researchers have recreated the human ascending sensory pathway in a lab dish, using organoids that model the key brain and ...

This study reveals that specific activation of layer V pyramidal neurons in the cingulate ... with a focus on the distribution of voltage-gated sodium channels in peripheral sensory axons.

Stanford Medicine investigators have replicated, in a lab dish, one of humans' most prominent nervous pathways for sensing ...

Four tiny 3D organs connected themselves in a lab dish, forming a replica of the human pain pathway, in a new study. The discovery allows scientists to better understand chronic pain and how pain ...

New research reveals that the enzyme HDAC5 plays a critical role in suppressing a gene (Scn4b) that regulates brain activity associated with drug-related memories, which are central to relapse in ...

Immediate use for the newly developed assembloids could include studying neurodevelopmental disorders such as autism.

This important computational study investigates homeostatic plasticity mechanisms that neurons may employ to achieve and maintain stable target activity patterns. The work extends previous analyses of ...

Neurons are cells in the body that are responsible for transmitting electrical signals through the nervous system. Different types of neurons affect the ability to move, which begins as an impulse, or ...

In summary, we observed that EP could directly enhance the excitability of pyramidal neurons in mPFC, which could be blocked by suppressing TRPC4 using Pico145 and CBD. It is widely agreed that TRP ...

Ask any smoker who has tried to quit and they’ll tell you it isn’t easy. But a recent study offers a surprising glimmer of ...