Suicide gene therapy consists of introduction into tumor cells of a non-mammalian gene encoding an enzyme (such as cytosine deaminase) that converts a non-toxic prodrug (5-fluorocytosine) into a ...

Gene-directed enzyme–prodrug therapy (GDEPT) 6 is a method of treating ... as a means to illustrate how modifications of the vector and suicide enzyme can be used to improve GDEPT.

“These first steps are really important,” she said. “The use of a ‘suicide gene’ in stem cell–derived therapies is certainly an obvious safety modification that a number of groups have been pursuing,” ...