The work of Ren et al. 3 suggests both a new inhibitory function and its surprising cellular mechanism. Further studies will be illuminating. Are there actually synaptic triads with specialized ...

Synaptic plasticity is the biological process ... The authors uncover slow, facilitating inhibitory connections between serotonin neurons in the dorsal raphe, refuting autoinhibition theories.

This paper explores how diverse forms of inhibition impact firing rates in models for cortical circuits. In particular, the paper studies how the network operating point affects the balance of direct ...

and associated bifurcations as function of relevant slow variables - such as extracellular potassium - and synaptic current; and whose output is both firing rate and impact on the slow variables - ...

Researchers have identified changes in brain connectivity before and after puberty that may explain why some children with chromosome 22q11.2 deletion syndrome are more susceptible to autism and ...

The brain really is an incredible organ, and neurons are the vital link between, well, everything. The brain is anything but set in stone; how we think, feel, reason, and understand the world changes ...

Here we provide the synaptic wiring diagram for sensorimotor circuits involved in learning and ... neurons reveal rules for monosynaptic connectivity and the existence of polysynaptic ensembles of ...

First author Hamilton Oh, now at Icahn School of Medicine at Mt. Sinai, New York, and colleagues identified these potential markers during a proteomics analysis of CSF from 3,397 participants in six ...

Think about your body’s natural cleaning systems that work around the clock. Your kidneys filter waste while your liver ...

Theravance Biopharma, Inc. ("Theravance Biopharma" or the "Company") (NASDAQ: TBPH) today announced new analyses from its previous Phase 3 program evaluating ampreloxetine, an investigational medicine ...

ABSTRACT: Alzheimer’s disease (AD) is highly prevalent in the elderly population and leads to AD patients’ higher mortality, low life quality, and lead to a huge economic burden on the health system.

Scientists have mapped the largest connectome — a 3D chart of brain cells and their links — by analysing a cubic millimetre ...