推荐语：本研究揭示了TCR-pMHC-CD8三分子复合物在机械力调控下的"捕获-滑动"键动态特性，解决了高亲和力TCR工程中自身肽交叉反应性的难题。作者通过单分子生物力学、MD模拟等技术，发现CD8通过力依赖的构象变化增强TCR对激动肽的识别，而过度强化的TCR-pMHC结合 ...

毫无疑问，T细胞通过TCR识别MHC分子呈递的抗原，是T细胞适应性免疫的基础，但是TCR和抗原的亲和力是否越高越好呢？近日有 ...

Here, we evaluate gastric and gastro-oesophageal junction (G/GEJ) adenocarcinomas for their expression of programmed death-ligand 1 (PD-L1), infiltration by CD8+ T cells and the relationship of both ...

Recently, the research team led by Professor Zhang Zhongtao and Professor Yao Hongwei from the General Surgery Center at ...

Multiple presentations demonstrate that T-knife’s proprietary next-generation technologies address important challenges with current cell therapy ...

Eric Gené and Jenson Brickley will compete for reigning champions Monlau Motorsport in this year’s TCR Europe series, racing a pair of CUPRA Leon VZ TCR cars. The Spanish team secured the drivers’ ...

DelveInsight’s Non-Hodgkin Lymphoma pipeline report depicts a robust space with 200+ Non-Hodgkin Lymphoma companies working ...

免疫治疗研发的新引擎 TCR（T细胞受体）是免疫系统中识别抗原的关键分子，其多样性决定了免疫系统对抗原的特异性识别能力。源品生物通过深入研究治愈后病毒性感染患者的免疫反应，成功获取到富集在效应CD8+T细胞及CD4+记忆T细胞簇中的TCR富集克隆型氨基酸 ...

近日，源品生物迎来里程碑时刻——自主研发的《TCR-enriched clonotype，acquisition method and use thereof》(TCR富集克隆型及其获取方法与用途)正式获美国专利商标局授权(专利号：US 12,252,526B2) ...

Nanoscience and technology is the branch of science that studies systems and manipulates matter on atomic, molecular and supramolecular scales (the nanometre scale). On such a length scale ...

The future of the Sattitla National Monument, located just south of the Oregon-California border in Modoc, Siskiyou and Shasta counties, is confused and uncertain.

该研究系统性阐释了非小细胞肺癌患者在新辅助免疫治疗联合化疗后的免疫微环境异质性，识别了患者在耐药机制方面的潜在差异，并开发了预测患者复发风险的新型生物学标志物，具有一定的基础研究与临床转化价值。