推荐语：本研究揭示了TCR-pMHC-CD8三分子复合物在机械力调控下的"捕获-滑动"键动态特性，解决了高亲和力TCR工程中自身肽交叉反应性的难题。作者通过单分子生物力学、MD模拟等技术，发现CD8通过力依赖的构象变化增强TCR对激动肽的识别，而过度强化的TCR-pMHC结合 ...

and characterize cross-reactive T cells using Nur77 reporter mice (C57BL/6 background), which transiently express GFP exclusively upon TCR engagement. We infected Nur77 mice with lymphocytic ...

T cell receptors (TCR) play a vital role in the immune system’s ability to recognize and respond to foreign antigens, relying on the highly polymorphic rearrangement of TCR genes. The recognition of ...

毫无疑问，T细胞通过TCR识别MHC分子呈递的抗原，是T细胞适应性免疫的基础，但是TCR和抗原的亲和力是否越高越好呢？近日有 ...

Here, we evaluate gastric and gastro-oesophageal junction (G/GEJ) adenocarcinomas for their expression of programmed death-ligand 1 (PD-L1), infiltration by CD8+ T cells and the relationship of both ...

Recently, the research team led by Professor Zhang Zhongtao and Professor Yao Hongwei from the General Surgery Center at ...

在血液科临床中，区分T细胞增殖是“反应性”还是“克隆性”（即恶性）是诊断与治疗的关键。传统的分子检测（如TCR基因重排分析）虽被视为“金标准”，但耗时长、成本高。 多参数流式细胞术（MFC）的TCR-Vβ库分析更为快速和灵活。一项来自意大利的20年 ...

Multiple presentations demonstrate that T-knife’s proprietary next-generation technologies address important challenges with current cell therapy ...

The persistence of a similar TCR repertoire at postoperative endoscopy was associated with smoking and disease recurrence. Patients with high clonality showed increased expression of genes associated ...

为探究 T 细胞受体（TCR）信号转导机制，研究人员发现 QRICH1 调控 CARD11，影响 CD8 + T 细胞功能。 T 细胞信号传导是一系列精心协调的分子相互作用，它将 T 细胞受体（TCR）的结合转化为影响细胞功能的基因表达变化。Carter 等人的研究揭示了富含谷氨酰胺蛋白 1 ...