Washington University School of Medicine in St. Louis, St. Louis, MO.

However, the impact of DuoHexaBody-CD37 on direct cytotoxic signaling has not yet been studied. Here we demonstrate that DuoHexaBody-CD37 induces direct cytotoxicity in DLBCL-derived tumor cell lines ...

At its third attempt, Mesoblast has secured FDA approval for Ryoncil as a treatment for children with graft-versus-host disease, the first-ever approval for a mesenchymal stromal cell (MSC ...

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As rivals race ahead in HBM3E, Samsung quietly builds momentum in next-gen HBM4 development, banking on its in-house chipmaking and packaging technologies. Save my User ID and Password Some ...

研究结论表明，Evobrutinib 能够抑制小胶质细胞中 BTK 的表达和激活，通过调节 TLR4/MyD88/NF-κB 信号通路，减少 M1 小胶质细胞介导的神经炎症，从而减轻缺血性脑卒中后的脑损伤，改善神经功能。这一研究为缺血性脑卒中的治疗提供了新的潜在药物和治疗靶点 ...

MyD88 非依赖途径则特定于 TLR3 和 TLR4 信号通路，通过 TIRAP/Mal 和 TRIF 激活，最终也能激活 NF-κB 和 MAPKs，诱导炎症细胞因子产生 。 同时，TLR 信号会受到多种分子的负调控，以防止过度免疫反应带来的不良后果。例如，ST2825、SOCS1 和 Cbl-b 抑制 MyD88 依赖途径的激活 ...