Discovery of innate immune receptor "brake" Siglec-E offers a novel therapeutic target to prevent organ transplant rejection ...

TNF receptor 1 (TNFR1) is expressed in most cell types, and can be activated by binding of either soluble TNF (solTNF) or transmembrane TNF (tmTNF), with a preference for solTNF; whereas TNFR2 is ...

Higher levels of soluble tumor necrosis factor (TNF) receptors were found in the stroma of control mice compared with the ...

TWEAK (tumour necrosis factor (TNF)-like weak inducer ... plasma-membrane-anchored receptor. The Fn14 gene is a growth-factor-inducible, immediate-early response gene, and it is highly expressed ...

AbolerIS Pharma has dosed the Phase I study’s first cohort subjects with its humanised anti-CD45 receptor-like protein C ...

and soluble TNF receptor 1 (sTNFR1). We are currently enrolling patients in a larger Phase 2b clinical trial that will investigate isomyosamine’s effect on cellular inflammation and recovery of ...

Company advances SL-325 program with an IND filing expected in the third quarter of 2025 – – Cash balance of approximately $60.9 million as of March 31, 2025, expected to fund operations into 2027 – ...

Schematic of TNF inhibitors and their mode of action. Receptor (i.e. etanercept, lenercept) and antibody based (i.e. infliximab, adalimumab, golimumab) anti-TNF biologics inhibit both solTNF and ...