Vogelmeier and colleagues (2011) set out to determine whether tiotropium (long-acting inhaled anticholinergic medication) was superior to salmeterol (long-acting inhaled β 2 agonist medication ...

Tiotropium (as bromide monohydrate ... COPD exacerbations were defined as a complex of respiratory symptoms (increase or new onset) of more than 1 of the following: cough, sputum, wheezing ...