Ubiquitin is a small ... cells and examined their interaction by immunoprecipitation (IP) with anti-Myc antibody. UbcH7 and, faintly, UbcH8 were co-immunoprecipitated with parkin, but no ...

Parabilis Medicines (formerly Fog Pharmaceuticals), a clinical-stage biopharmaceutical company committed to creating extraordinary medicines for people living with cancer, is presenting preclinical ...

Center for BioAnalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale, University of Science and Technology of China, Hefei 230026, China Center for BioAnalytical Chemistry, ...

You will be redirected to our submission process. Ubiquitination, a critical post-translational modification in eukaryotic cells, involves the attachment of the ubiquitin moiety to substrate proteins ...

Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fujian Medical University, Fuzhou, 350122, China ...

Explore the impact of 3D models in drug discovery and how they enhance predictive insights in pre-clinical research.

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

Taken together, these findings demonstrate that interferon triggers PARP14-mediated ADP-ribosylation in p62 bodies, which requires an active ubiquitin-proteasome system. Interferon induces the ...

Harmful infectious organisms are identified as invaders due to their antigens (distinct molecules on their surface). Each antibody produced by your immune system binds to a specific antigen and then ...

University of Virginia, Charlottesville, VA.