Ubiquitylation is a reversible post-translational modification involved in a myriad of cellular functions. A superfamily of approximately 100 ubiquitin-specific proteases, called deubiquitylating ...

Specific ubiquitin–UBD interactions are crucial for the regulation of multiple cellular functions, including protein stability, receptor trafficking, DNA damage responses and inflammatory pathways.

An enzyme called Ubiquitin-specific peptidase 5 is a key factor in protein quality in heart muscle cells ...

Ubiquitin ligases regulate many processes in ... Dimerization is, therefore, an important regulatory mechanism." "If HACE1 no longer functions correctly in the cell or is missing altogether ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

E1 enzymes facilitate conjugation of ubiquitin and ubiquitin-like proteins through adenylation ... These studies were followed by an in vivo screen in yeast that uncovered at least three critical E2 ...

An enzyme called Ubiquitin-specific peptidase 5 is a key factor in protein quality in heart muscle cellsA disrupted protein ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

During ubiquitination, a small protein known as ubiquitin is attached to other ... are involved in ubiquitination's diverse ...