Specific ubiquitin–UBD interactions are crucial for the regulation of multiple cellular functions, including protein stability, receptor trafficking, DNA damage responses and inflammatory pathways.

Ubiquitylation is a reversible post-translational modification involved in a myriad of cellular functions. A superfamily of approximately 100 ubiquitin-specific proteases, called deubiquitylating ...

A disrupted protein degradation process in heart muscle cells can lead to a range of severe heart diseases. In the case of ...

The activation of ubiquitin-mediated proteolysis resulted in PDE9A degradation ... Granule cells, which are pervasively distributed within the hippocampus and cerebellum and are instrumental in ...

An enzyme called Ubiquitin-specific peptidase 5 is a key factor in protein quality in heart muscle cellsA disrupted protein ...

Given our findings that IFT172 possesses both ubiquitin-binding and potential ubiquitin ligase activities, we propose that IFT172 could directly influence the fate of ubiquitinated TGFB receptors.

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

Executive function describes a set of cognitive processes and mental skills that help an individual plan, monitor, and successfully execute their goals. The “executive functions,” as they’re ...

The assay was carried out using 5 nM USP30 and reactions were started by simultaneous addition of 180 nM ubiquitin-rhodamine 110 to all 384 wells using the FLIPR Tetra (Molecular Devices) dispense ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...