Anti-VEGF therapy improves outcomes in retinal diseases by targeting neovascularization and macular edema, crucial in conditions like AMD and diabetic retinopathy. Optical coherence tomography is ...

随着各大药企陆续披露2024年财报，畅销药排行榜单已经清晰。2024年，12款创新药销售额突破100亿美元，药王Keytruda更是逼近300亿美元。TOP10榜单中，有7款仍处于高速增长阶段，包括肿瘤免疫的Keytruda，血液瘤的CD38抗体。代 ...

There has been a lot of talk about drugs targeting both PD-1 and VEGF stealing the crown held by MSD's Keytruda in cancer immunotherapy. Now, the company has made a move to try to make sure it isn ...

Pathogenic variants were then studied in vivo using a transgenic zebrafish model. Conclusions Our study highlights the specific role of BMP/TGF-β and VEGF/VEGFR signalling in the aetiology of BAVM and ...

1 Department of Oncology, Harbin Medical University Cancer Hospital, Harbin, China 2 Department of Gastroenterology and Hepatology, Tianjin Second People’s Hospital, Tianjin, China The cancer-immunity ...

VEGF165 is the most abundant splice variant of VEGF-A and is produced by various cell types, including endothelial cells, macrophages, and T cells. It plays a critical role in angiogenesis ...

CCK-8 实验、EdU 染色、伤口愈合实验、Transwell 实验和管形成实验等结果显示，ApoVs 能显著增强 HUVECs 的增殖、迁移和血管生成能力，同时 qPCR 分析发现，ApoVs 处理后，HUVECs 中血管内皮生长因子（VEGF）和血管生成素 2（ANG2）等血管生成相关基因的表达显著上调。