Purpose: The chemical interactions that cause drug incompatibility in solutions, with emphasis on the acid-base and ionized-nonionized forms of organic, weak, electrolyte drugs, are examined.

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[22,26,27,31] Table 1 describes the letter symbols used in this review to represent the organic drug ions and molecules ... of the HA or H 2 A forms, making 1% or more of the HA nonionized form ...