Genetics significantly impact cancer risk, particularly in inherited mutations like BRCA1/BRCA2, which increase ...

"This research is a major advancement in understanding the role of many BRCA2 variants in cancer predisposition ... of their VUS as the ClinVar BRCA1/2 expert panel and testing laboratories ...

Researchers at Peter Mac have uncovered potential new heredity genes that might be responsible for causing one of the most ...

Susan M. Domchek, MD, FASCOPHILADELPHIA - Susan M. Domchek, MD, FASCO, has been recognized by the American Society of Clinical Oncology (ASCO) with ...

“A disease-causing mutation is not absolute; this means that if there are 100 women with the same disease-causing mutation in a specific gene [e.g. BRCA1 or BRCA2], between 60 to 80 of them will ...

On World Cancer Day, we look at advances in cancer research, prevention and treatment that bring new hope and are extending ...

The health technology assessment agency has recommended that the drug be used on the NHS in England and Wales to treat adults with HER2-negative, locally advanced or metastatic breast cancer with ...

The researchers completed a comprehensive functional assessment of all possible variants within the crucial DNA-binding domain of BRCA2, resulting in the clinical classification of 91% of variants ...

This treatment targets adults with HER2-negative, locally advanced or metastatic breast cancer who have germline BRCA1 or BRCA2 mutations, following chemotherapy. Germline BRCA1 and BRCA2 mutations ...