Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...

The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a ...

During the endosome–lysosome transition, the compartmental pH drops, which is conducive to the function of lysosomal acid hydrolases. Here the authors show that the biological fate of rare earth ...

A new set of genes that contribute to Parkinson’s disease risk has been identified.

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

This month's cover highlights the article Deubiquitinating enzymes UBP12 and UBP13 stabilize the brassinosteroid receptor BRI1 by Yongming Luo, Takeo Sato and colleagues. Loss of the deubiquitinating ...