其激活过程如下:Wnt 蛋白与细胞膜上的 Frizzled(FZD)受体结合,激活低密度脂蛋白受体相关蛋白 5 和 6(LRP5/6)共受体;这一过程触发 Dishevelled(DVL)介导的 β-catenin 破坏复合物(DC)解离,DC 由 AXIN、APC、GSK - 3β 和 CK - 1α 组成,DC 解离后失去降解 β-catenin 的 ...
The authors find that the expression of notum, a Wnt inhibitor that is triggered after any cut ... Further analysis should be shown: i) Demonstration that the intensity of the band increases after APC ...
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