In HCC, mutations in key components of the Wnt pathway, including β-catenin (encoded by CTNNB1), AXIN, and APC, lead to sustained activation of this pathway. This dysregulation drives HCC ...

其激活过程如下：Wnt 蛋白与细胞膜上的 Frizzled（FZD）受体结合，激活低密度脂蛋白受体相关蛋白 5 和 6（LRP5/6）共受体；这一过程触发 Dishevelled（DVL）介导的 β-catenin 破坏复合物（DC）解离，DC 由 AXIN、APC、GSK - 3β 和 CK - 1α 组成，DC 解离后失去降解 β-catenin 的 ...

In HCC, mutations in key components of the Wnt pathway, including β-catenin (encoded by CTNNB1), AXIN, and APC, lead to sustained activation of this pathway. This dysregulation drives HCC progression ...

Introduction: Lung adenocarcinoma (LUAD) therapies are plagued by insufficient immune infiltration and suboptimal immune responses in patients, which are closely associated with the hyperactive ...

The authors find that the expression of notum, a Wnt inhibitor that is triggered after any cut ... Further analysis should be shown: i) Demonstration that the intensity of the band increases after APC ...

Mounting evidence also showed that critical developmental pathways, namely, bone morphogenetic protein (BMP), NOTCH, and WNT, interact each other and play an important role in postnatal bone ...

Canonical Wnt signaling regulates bone formation and is essential for osteoblast proliferation, differentiation, function and survival. Antiresorptive agents are the mainstay of current ...

Liver cancer, particularly hepatocellular carcinoma (HCC), is one of the most common and aggressive malignancies worldwide. Immunotherapy has shown promising results in treating HCC, but its efficacy ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The prevailing view on post-translational ...