Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts.

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming ...

Hypospadias is characterized by an ectopic urethral opening and abnormal penile curvature, affecting approximately 1 in 200 live male births.

A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of ...

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts.

Genetics and Molecular Biology considera contribuições que apresentem os resultados de pesquisas originais nas áreas de genética, evolução e disciplinas científicas relacionadas. Genetics and ...

The research highlights how SOX9 regulates critical molecular pathways involved in urethral development, including the Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition (EMT). The ...

Molecular modelling encompasses all theoretical methods and computational techniques used to mimic and study the structure and behaviour of molecules, ranging from small chemical systems to large ...

On the occasion of the 30th anniversary of the discovery of the first mammalian Wnt-gene, this Focus issue features a personal perspective from Roel Nusse and Harold Varmus on past, current and future ...

为解决非小细胞肺癌（NSCLC）吉西他滨耐药机制不明及缺乏有效治疗靶点问题，南昌大学研究人员开展 hsa_circ_0125356 相关研究，发现其可调控 WNT 通路促进耐药，为治疗提供新方向。 在癌症的世界里，非小细胞肺癌（NSCLC）堪称 “头号杀手”，严重威胁着人类的 ...