Sapience Therapeutics, Inc., a clinical-stage biotechnology company focused on the discovery and development of peptide therapeutics to address oncogenic and immune dysregulation that drive cancer, ...

Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts.

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming ...

Hypospadias is characterized by an ectopic urethral opening and abnormal penile curvature, affecting approximately 1 in 200 live male births.

A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of ...

As the official payment services sponsor of Canada Soccer, Visa is offering cardholders an opportunity to purchase tickets in advance of the public on-sale date. As Canada Soccer’s preferred payment ...

As the official payment services sponsor of Canada Soccer, Visa is offering cardholders an opportunity to purchase tickets in advance of the public on-sale date. As Canada Soccer’s preferred payment ...

"We found that organoids bearing MYC on extrachromosomal DNA could shift their dependency on WNT," explains Antonia Malinova ... "Perhaps pushing cancer cells to dial MYC up to a point where they ...

Department of Molecular Pharmacology, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands; a.i.r.spanjer{at}rug.nl Rationale We have previously shown increased ...

Colonic tissues and cell lines were analysed by histopathology and molecular-biology methods. Results A significant increase in the ... In vitro, β-catenin knockdown decreased ObR expression, and ...