We know today that Wnt and a handful of other signalling systems (Notch, Hedgehog, TGFβ (transforming growth factor-β)–BMP (bone morphogenetic protein) and receptor tyrosine kinases) are major ...

A growing body of research highlights the crucial role of the Wnt signaling pathway, especially its β-catenin axis, in HCC. This pathway regulates essential processes such as cell proliferation ...

Subscribe to our newsletter for the latest sci-tech news updates. Identification of WNT signaling as a key driver of ...

The process by which cells orient themselves correctly within the plane of an epithelial tissue is known as planar polarity. The molecular mechanism of planar polarity is understood best in fruit ...

A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of ...

ST316, a β-catenin/BCL9 antagonist, demonstrated safety, target engagement, and early antitumor activity in advanced solid ...

Researchers have answered a long-standing question in developmental biology by revealing the driving forces of the massive cell movements that occur during early embryonic development ...

Novel driver genes for early intervention Through the study, Dr. Lin's team identified several key genetic alterations ...

Hypospadias is characterized by an ectopic urethral opening and abnormal penile curvature, affecting approximately 1 in 200 live male births.

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...