此前已证实阿霉素（ADR）可诱导小鼠足细胞衰老。为进一步探究这一过程的机制，研究了雷莫丁（Remodelin）处理后肾小球中衰老相关蛋白的变化。蛋白质印迹（WB）分析显示，雷莫丁可减轻阿霉素诱导的 P53、P21、P16 ...

Mattress weight capacity determines which body types can comfortably use a mattress without sacrificing support or reducing the longevity of your bed. The standard mattress weight limit is around ...

并降低了肾小球中 P53、P21 和 P16 的表达水平。为证明这些变化特异性地发生在足细胞中，通过共染 P21 和 P16 与足细胞标志蛋白 WT-1 进行了免疫荧光 ...

They also identify a P53/MCL-1/BAK axis balancing proliferation and death of activated hair follicle stem cells to ensure proper hair growth. Fetal cell ablation models are essential for ...

Weight-Loss Surgery Lowers Risk of Developing Complications of Liver Disease in Patients With Cirrhosis and Obesity Jan. 27, 2025 — A study shows that patients with obesity and fatty liver ...

PTX-252 is a small molecule designed to remove toxic heavy metals from the tumour microenvironment, improving the functioning of the tumour suppressor protein p53, thus increasing the sensitivity of ...

The earliest observations on population patterns of disease and how they might inform medical practice probably occurred during the 17th century, and they continue to the present day, with ...

Mar. 13, 2025 — A study shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United States ...