此前已证实阿霉素（ADR）可诱导小鼠足细胞衰老。为进一步探究这一过程的机制，研究了雷莫丁（Remodelin）处理后肾小球中衰老相关蛋白的变化。蛋白质印迹（WB）分析显示，雷莫丁可减轻阿霉素诱导的 P53、P21、P16 ...

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Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...

Unresectable (sometimes referred to as inoperable) cancer cannot be completely removed with surgery. This can be due to a variety of reasons, including tumor size, stage, and location. Although an ...

Dana Schulz is an experienced editor, writer, and content strategist who is just as likely to be crunching the ...

But in July after the wedding, Robinson quickly lost an incredible amount of weight — approximately 28 lbs. — prompting another visit to the doctor. His now-wife, Jasmin, “stormed in” and ...

That’s up from 731 million adults and 198 million young people in 1990, as recent generations gain more weight faster and earlier in life. In high-income countries, for example, about 7 per cent ...

We found that the three DNA-damaging drugs, namely Nutlin, Doxorubicin, and 5-Fluorouracil (5-FU), stabilized p53 and concurrently repressed BLM and RAD51 in both HCT116 WT and HCT116 p21−/− cells but ...