The very first cells obtained their energy from geochemical reactions. LMU researchers have now managed to recreate this ...

This new review article published in Genes & Diseases sheds light on the pivotal role of fatty acid oxidation (FAO) in the ...

Tumor metabolism plays a pivotal role in shaping immune responses within the tumor microenvironment influencing tumor progression, immune evasion, and the efficacy of cancer therapies. Radiotherapy ...

Cohen, MD, PhD, from Brigham and Women’s Hospital, these inhibitors may offer a new treatment approach by targeting acetyl-CoA levels and disrupting disease-driving pathways in PSC. Esperion’s ...

Recent studies have shown that renal tubular epithelial cells (RTECs) injury plays an important role in the occurrence and progression of DKD. The glycolipid metabolism disorders are a vital factor ...

Furthermore, we illustrated the mechanism behind acetoacetate-induced histone Kacac through enzymatic conversion by acetoacetyl-CoA synthetase (AACS). Together, this study delves into the complex ...

Metabolic interventions targeting acetyl-CoA levels and compounds like spermidine and fisetin also show promise in mitigating age-related cognitive impairment. Like the other organs in our body ...

Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, Chongqing Institute of ...