Lutris Pharma, a clinical stage biopharmaceutical company focused on improving anti-cancer therapies by reducing cutaneous ...

Conclusion: Indirubin, the primary bioactive metabolite of Isatidis Folium, exerts protective effects against sepsis by targeting the EGFR/SRC/PI3K and NF-κB/MAPK signaling pathways in macrophages.

Cells were seeded in 6-well plates, and starved in serum-free medium for 24 h. Then cells were treated with indicated concentrations of compounds for 2 h and EGFR signaling was stimulated with 50 ...

Department of Physiology, State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical ...

From April 25 to 30, 2025, the American Association for Cancer Research (AACR) Annual Meeting will take place in Chicago. CStone will showcase its latest preclinical studies on five internally ...

本研究通过多组学分析揭示Egf诱导的组织特异性信号传导，为理解Egfr（表皮生长因子受体）相关疾病提供新视角。 Epidermal growth factor receptor (Egfr) -driven signaling is central to fundamental cell processes in various tissues and the dysregulation of ...

The Rybrevant-Lazcluze combo significantly reduced the risk of death by 25% versus Tagrisso in patients with newly diagnosed advanced EGFR-mutated NSCLC, according to data from the phase 3 ...

The patent describes small-molecule inhibitors designed to block the activity of EGFR, RAF1, and STAT3. These inhibitors prevent the activation of signaling pathways that promote tumor growth and ...