The lab of Filippo Veglia, Ph.D., at The Wistar Institute has discovered a previously unknown mechanism for how aggressive ...

Histone acetylation has been shown to play a crucial role in memory formation, and histone deacetylase (HDAC) inhibitor sodium butyrate (NaB) has been demonstrated to improve memory performance and ...

At the heart of the deal is the drug candidate dordaviprone, which is months away from a regulatory verdict for its use in H3 ...

A new review highlights the pivotal role of LSD1 (lysine-specific demethylase 1) in regulating critical cellular processes ...

Researchers at Fred Hutch Cancer Center have discovered an overlooked mechanism driving aggressive breast and brain tumors ...

Epigenetic changes include covalent modifications to the DNA bases or histone proteins that make ... and transmitted through DNA replication. The structure of chromatin bound by Polycomb ...

The exact molecular functions of Polo-like kinase 1 (PLK1) in mitotic prophase are not fully understood. This study shows ...

Plants are very important living things. They have lots of jobs, such as providing animals with food and releasing oxygen into the air. To survive and carry out these jobs, they all need three ...

除了上文中浅析的首创性小分子药物, 本年度批准上市的新药还有多款值得深入挖掘和分析, 例如, 显像药物氟 [18F]比哒嗪 (flurpiridaz F18)是用于心肌缺血和梗死诊断评估的新型正电子发射断层扫描心肌灌注成像示踪剂; IDH1/2双重抑制剂伏昔尼布 (vorasidenib)则是几十年来首个用于神经胶质瘤治疗的新分子, ...

Each journal is staffed by professional editors who work in collaboration with one another and our international Editorial Advisory Boards of leading scientists. Please feel free to contact any of the ...