为探究自闭症谱系障碍（ASD）的分子机制，研究人员以 BTBR 小鼠为模型，开展前额叶皮层（PFC）的 mRNA 和 miRNA 表达谱研究。结果发现 1063 个差异表达基因和 48 个差异表达 miRNA，明确二者复杂关系。该研究为理解 ASD 发病机制及治疗提供新视角。

丁苯酞作为一种神经保护药物，在治疗缺血性脑卒中方面展现出了潜力，它可以通过扩张脑血管、改善脑血流、减轻氧化应激等多种方式发挥作用。然而，其具体的作用机制却像一团迷雾，并不完全清楚。与此同时，信使核糖核酸（mRNA，作为蛋白质合成的模板，在生物过程中起着核心作用）和长链非编码核糖核酸（lncRNA，虽不编码蛋白质，但在基因表达调控中意义重大）在脑血管疾病的发生发展中扮演着重要角色，二者的共表达网络能 ...

The following is a summary of “LncRNA-mRNA co-expression network in the mechanism of butylphthalide treatment for ischemic ...

Advancements in mRNA vaccine technology are reshaping medicine, addressing challenges and expanding applications from ...

In recent years, mRNA technology enabled the rapid development of vaccines to fight COVID-19, saving millions of lives.

This study provides proof-of-principle data for the use of trained immunity to modulate macrophage interactions with tumours. The study makes a valuable contribution to the field of trained immunity.

In the default model, the graph representing each individual enhancer can be arbitrarily complicated. To show how the ABC Score formula can arise from the default model, we need to impose the further ...

This unique property facilitates membrane fusion-mediated endosomal escape, leading to improved mRNA expression in the liver compared to conventional phospholipids such as DSPC and DOPE.

A team of researchers led by Dr. Kim V. Narry, director of the Center for RNA Research at the Institute for Basic Science (IBS), has uncovered a key cellular mechanism that affects the function of ...

Writing in Molecular Therapy Nucleic Acids, researchers hypothesized that using poly(A) tail mimetics to enhance mRNA expression from haploinsufficiency-associated genes could be a disease-modifying ...