Ferroptosis is a novel form of programmed cell death characterized by iron-dependent accumulation of reactive oxygen species (ROS) and lipid peroxidation. The execution of ferroptosis is intricately ...

Ferroptosis has emerged as a key player in neurodegenerative diseases, contributing to neuronal damage through iron accumulation and oxidative stress. In Alzheimer’s disease and Parkinson’s diseases, ...

This is an important study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. With convincing evidence, the authors have demonstrated that TFAM's counteractive ...

Mitochondrial diseases, arising from mutations in mitochondrial DNA (mtDNA), are a diverse group of disorders that lead to severe conditions. Expression of mtDNA is a prerequisite for ATP production ...

这篇研究发现低剂量普瑞沙替尼（prexasertib）可通过损伤线粒体 DNA（mtDNA）修复机制，诱导 mtDNA 释放激活 STING 介导的先天免疫，还能与免疫检查点阻断剂协同增效，为优化肿瘤免疫治疗、规避药物毒性提供了新策略，极具科研与临床价值。 ### 研究背景 检查点 ...

But according to a recent study published in the journal Environmental Research, exposure to green spaces may have a positive relationship with the Mitochondrial DNA copy number, or mtDNA-CN, in ...

This manuscript by Kremer et al. characterizes the tissue-specific responses to changes in TFAM levels and mtDNA copy number in prematurely aging mice (polg mutator model). The authors find that ...

Within the core program, TFE3 fusions directly regulate genes involved in ferroptosis resistance and oxidative phosphorylation metabolism (OxPhos). Consequently, human tRCC tumors display high OxPhos ...

本文全面综述了线粒体 DNA（mtDNA）在免疫反应中的作用。阐述了 mtDNA 释放的机制、激活免疫反应的方式，以及在多种疾病（如血管、代谢、肾脏疾病等）中的影响，并探讨了相关研究策略，为理解疾病发病机制和治疗提供新视角。文章发布在《Cell Communication and ...

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