HC Bioscience is shutting down after conducting preclinical models for a transfer RNA (tRNA) asset designed to treat ...

Their findings revealed that these genes play a role in male fertility and in generating small RNA molecules in mature sperm known as tRNA fragments (tRFs). tRFs are created by cleavage of transfer ...

This new article published in Genes & Diseases highlights the critical role of tRNA-derived small RNAs (tsRNAs) in digestive ...

This new article published in Genes & Diseases highlights the critical role of tRNA-derived small RNAs (tsRNAs) in digestive ...

Defects in tRNA biology, such as mutations in tRNA genes or aminoacyl-tRNA synthetases, can lead to various diseases, including: Understanding the mechanisms of tRNA-related diseases and the potential ...

More information: Sophia Zborowsky et al, Adaptive loss of tRNA gene expression leads to phage resistance in a marine Synechococcus cyanobacterium, Nature Microbiology (2025). DOI: 10.1038/s41564 ...

Prokaryotic organisms contain one type of rRNA gene that encodes three distinct ... which is the 3' end of the tRNA, binds to its corresponding amino acid at an attachment site that is also ...

Some examples of anticodon modifications include: Mutations in tRNA genes or defects in tRNA modifications can lead to various genetic diseases. These alterations can affect the structure and function ...

A recent study published in the Genes & Diseases journal by researchers at Shanghai Jiao Tong University School of Medicine implicates isoleucyl-tRNA synthetase 2 (IARS2) in promoting the ...

The tRNA that corresponds to the second codon can ... and thereby fine-tune gene expression.

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...