Processing of the primary transcripts involves RNA excision and modification. The tRNA genes mark most of the junctions between mitochondrial protein-coding and rRNA genes. The first step in the ...

HC Bioscience is shutting down after conducting preclinical models for a transfer RNA (tRNA) asset designed to treat ...

Defects in tRNA biology, such as mutations in tRNA genes or aminoacyl-tRNA synthetases, can lead to various diseases, including: Understanding the mechanisms of tRNA-related diseases and the potential ...

While, in theory, eukaryotes need to encode approximately 42 different tRNA genes—to decode the 61 messenger RNA (mRNA) triplet codons that specify an amino acid—the genomes of vertebrates contain ...

This new article published in Genes & Diseases highlights the critical role of tRNA-derived small RNAs (tsRNAs) in digestive ...

This new article published in Genes & Diseases highlights the critical role of tRNA-derived small RNAs (tsRNAs) in digestive ...

Their findings revealed that these genes play a role in male fertility and in generating small RNA molecules in mature sperm known as tRNA fragments (tRFs). tRFs are created by cleavage of transfer ...

Some examples of anticodon modifications include: Mutations in tRNA genes or defects in tRNA modifications can lead to various genetic diseases. These alterations can affect the structure and function ...

A recent study published in the Genes & Diseases journal by researchers at Shanghai Jiao Tong University School of Medicine implicates isoleucyl-tRNA synthetase 2 (IARS2) in promoting the ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...