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生物通
19 天
PYROXD1 保护人 tRNA 连接酶复合物免受氧化失活的机制解析
然而,tRNA-LC 的催化亚基 RTCB(RNA 3'-phosphate cyclase and tRNA ligase 1)却面临着一个严峻的 “挑战”。RTCB 的催化中心含有一个高度保守且反应性很强的半胱氨酸残基,在有氧条件下,尤其是在铜离子等金属离子存在时,这个半胱氨酸残基极易被氧化,导致 RTCB 失活 ...
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