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生物通
59 分钟
基于块 LASSO 的多基因评分:解锁全基因组分析新潜能,推动精准医学 ...
在多基因评分(PGS)研究中,传统方法存在计算效率低、内存需求大等问题。为解决这些难题,研究人员开展了 “blockLASSO” 方法训练 PGS 的研究。结果表明,该方法在不同生物样本库和祖先群体中,与传统 LASSO 效果相似,但计算效率更高,为探索性研究提供了新途径。
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