8). Figure 1: A sequence alignment of amino-acid residues near the H-9 (α9) and H-10 (α10) helix of class C β-lactamases with extended substrate spectrum.

This project will develop state of the art wearable sensors to measure antimicrobial resistance, which is key to prevent antibiotic misuse.

The inhibitor prevents bacterial enzymes such as metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs) from breaking down the antibiotic before it has its desired effect to treat the infection.

† VIMs are made up of 266 amino acid residues with the exception of VIM-7 (265 residues) and VIM-18 (262 residues). VIM-21, -22 and -27 have been assigned in the Lahey Clinic [201], but there ...