CRISPR–Cas12a has a low tolerance for base ... Versatile editors for AAV or RNA delivery To support RNA-based delivery, Ensoma engineered the RNA-processing activity to produce mature messenger ...

They are considered one of the field’s most effective delivery tools ... also now exploring ways to combine AAV vectors with gene-editing tools such as CRISPR/Cas9,” he says.

A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that ...

On this episode of GEN Live, we’ll talk to experts in delivery with a focus on AAV vectors. We’ll discuss the successes the field has experienced, the challenges that remain, new technologies ...

A research team has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than ...

To assist researchers in the selection of the optimal AAV vector for their application, we have generated a detailed map of viral delivery to tissues in mice, the most commonly used experimental ...

CRISPR-Cas holds great promise for treating and curing human ... “That could be huge in terms of simplifying gene editing through the use of these AAV delivery vehicles.” In the past, researchers have ...

Gene editing technologies have cemented their place as a valued method in the biological toolkit used by researchers around the globe.

Mitochondrial diseases, arising from mutations in mitochondrial DNA (mtDNA), are a diverse group of disorders that lead to severe conditions. Expression of mtDNA is a prerequisite for ATP production ...

Furthermore, the ABE-based gene editing approach is expected to be less toxic and safer than the conventional CRISPR-Cas9 technology. The AAV genome editing therapy we developed can also be ...

"To assist researchers in the selection of the optimal AAV vector for their application, we have generated a detailed map of viral delivery to tissues in mice, the most commonly used experimental ...