Details for the poster presentation: Title: TACTI-004: a double-blinded, randomized phase 3 trial in patients with advanced/metasttic non-small cell cancer receiving eftilagimod alfa (MHC class II ...

Dec. 10, 2024 — In a single IV injection, a gene therapy targeting cBIN1 can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the ...

Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...

The APC/C ubiquitylates histones to regulate gene expression in pluripotent cells. Here, the authors pair cryo-EM and biochemical and biophysical assays to show that instead of modifying ...

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide, with approximately 20% of patients ...

Trump delays 25% Mexico tariffs after speaking with President Sheinbaum, citing progress on fentanyl. Tariffs on China and ...

Wall Street sells off as tariff whiplash and falling AI stocks send Nasdaq more than 10% below record ...

"We've discovered mutations in genes like APC, TP53, and KRAS that tend to appear ... Lin Cong's team analyzed tumor gene expression profiles and identified five prognostic subtypes with distinct ...

Objective Sporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examine the key mutational and transcriptomic alterations in an organoid ...

2.4 Analysis of the degree of immune infiltration in tumor tissue ESTIMATE (Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data) is a package for predicting tumor ...

Background and aims Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC). International guidelines recommend surveillance intervals of 1–2 years. However, ...