Colorectal cancer is no longer a disease of older people. People in their 50s, 40s and younger are increasingly being ...

The APC gene was discovered by Kimmel Cancer Center researchers in 1991, and mutations in APC occur in over 90% of all colorectal tumors. "HMGA1 functions like a molecular 'key' that 'opens ...

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The APC/C ubiquitylates histones to regulate gene expression in pluripotent cells. Here, the authors pair cryo-EM and biochemical and biophysical assays to show that instead of modifying ...