为探究 DNA 损伤修复机制，研究人员发现 NEMO 可介导 ATM-IKK α 修复 DNA，且与癌症预后相关。 编辑总结：DNA 损伤会被一系列在损伤位点聚集的蛋白质复合物识别并修复。激酶 ATM（Ataxia Telangiectasia Mutated）是初始反应的主要蛋白，有助于激活其他修复蛋白。Alonso-Mara?

研究人员针对 ATM 突变前列腺癌开展研究，发现 ATR 和 DNA-PKcs 双重抑制有疗效，Compound B 或可用于联合放疗。 在晚期去势抵抗性前列腺癌（CRPC）中，DNA 损伤反应（DDR）基因共济失调毛细血管扩张突变（ATM）发生突变的情况较为常见。尽管聚（ADP - 核糖）聚合酶 ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

DSBs and DNA Rearrangements in Cancer Cells Together with a variety of other molecules, ATR and ATM kinases are key factors for the surveillance of DNA replication, and prevent chromosome breakage ...

Dramatic footage shows the moment a man attempted to steal an ATM, with DNA later linking him to the crime. Shortly after 3am on December 3 2023, Tommy Mitchell used a stolen vehicle as he tried ...