Edited by Donald Ort, University of Illinois at Urbana Champaign, Urbana, IL; received December 10, 2024; accepted January 28, 2025 ...

TMC207 inhibits the proton pump of mycobacterial ATP synthase, a critical enzyme in the synthesis of ATP for Mycobacterium tuberculosis. Resistance is achieved through mutations at position 63 or ...

研究结论表明，线粒体蛋白水平可能与先天性心脏、泌尿、神经系统、耳部和肢体畸形存在因果关系。这一发现突出了线粒体功能障碍在结构性出生缺陷发病机制中潜在的病因学作用。丙酮酸脱氢酶激酶同工酶 1 和 ATP 合酶 β 亚基线粒体水平降低与先天性心脏病风险降低相关，说明丙酮酸代谢和 ATP 生成过程的紊乱可能干扰心脏发育过程，导致心脏结构缺陷。39S 核糖体蛋白 L14 ...

Bedaquiline, the first new TB drug approved in 40 years by the USFDA, faced several challenges, including initial trial failures and concerns over toxicity. With persistence and refined trials, it ...

Photobiomodulation Therapy (PBMT) uses red and near-infrared light to enhance cellular repair, reduce inflammation, and support neurological and skin health. Learn how it works, how it's different ...

Today marks World TB Day 2025 with the WHO calling for more investment into TB treatment and research globally.

Dubbed the “premium tour,” it included Wimbledon and the Australian, French and U.S. Opens, alongside 10 more top-level tournaments run through the ATP (men’s) and WTA (women’s ...

基于结构的数字化药物研发 ：水木药业基于自有冷冻电镜集群、GPCR平台和AI技术,全球第一个成功获取了新一代肥胖靶点GPR75的高分辨冷冻电镜结构,大幅提升了小分子药物发现和优化效率,有机会成为超越斯美格鲁肽的新一代减肥小分子药物。

A. As of April 2025, Jannik Sinner is the ATP World No. 1. Q. Who won the 2025 Australian Open men's singles title? - + A. A. Jannik Sinner won the 2025 Australian Open men's singles final ...