Lysosomes are subcellular organelles that are mainly responsible for degradation of proteins internalized by cells by endocytosis and phagocytosis. Upon uptake, proteins and soluble components ...

This will extend the usefulness of our antibiotics. Anne also works to improve science teaching. The molecular chaperone CCT and the cytoskeleton: understanding the interplay between the folding of ...

After further analysis, the researchers found the drug relies on lysosomes, which are one of the cells' major recycling centers, and on an enzyme called cathepsin B. In Alzheimer's disease ...

According to the authors in Science Advances, this mechanism relies on a protein complex known as retromer and the lysosomes—cell organelles containing digestive enzymes. These special cellular ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The specific lipid composition of cell membrane microenvironments plays a critical ...

Its dual interaction with actin filaments and microtubules highlights its essential role in cytoskeletal organization, such as cell division, apoptosis, and possibly tumorigenesis. However, the ...

The paper S. Kaur et al., “An unmet actin requirement explains the mitotic inhibition of clathrin-mediated endocytosis,” eLife, 3:e00829, 2014. For decades, scientists observed clathrin-mediated ...

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In pink, wild type cells expressing gamma actin. In black, knock-out cells that do not express gamma actin. The yellowish lines reveal the tortuous nature of the ...

aThe Cardiac Exercise Research Group at the Faculty of Medicine and Health Sciences, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway ...

Lysosomes are dynamic organelles critical for cellular degradation and signaling, safeguarded by a limiting membrane that prevents leakage of harmful contents into the cytoplasm. Upon lysosomal damage ...