They are integral allosteric membrane proteins comprising five identical or homologous subunits symmetrically arranged around a central ionic channel. The acetylcholine (ACh)-binding sites on the ...

A novel, allosteric and highly potent USP1 inhibitor ... LAE002 (afuresertib) is a potent AKT inhibitor that inhibits all three AKT isoforms (AKT1, AKT2 and AKT3) as well as one of the only ...