Scientists have discovered a new protein pathway involved in neurodegeneration by studying “mini-brain” organoids made from patients with frontotemporal lobar degeneration (FTLD).

The PI3K/AKT/mTOR (PAM) signaling pathway is a classical pathway that is aberrantly activated in cancer cells and promotes the tumorigenesis, metastasis, resistance to castration therapy, ...

本文聚焦 PI3K/AKT 信号通路在缺血再灌注（I/R）损伤中的作用，总结相关分子机制及预防策略。 缺血性疾病中 PI3K/AKT 等信号 ...

Loss of Obsl1 mostly affects mitochondrial size. Only the combined loss of both proteins gives rise to the diastolic dysfunction phenotype, signified by altered cardiac metabolism, disrupted ...

After autophagy was blocked, the therapeutic effect of BSP was reversed. In addition, BSP activated the PI3K/AKT signaling pathway. Discussion: Studies have shown that BSP induces autophagy by ...

Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China ...

International Cooperation Base for Active Substances in Traditional Chinese Medicine in Hubei Province, School of Pharmaceutical Sciences, South-Central Minzu University, 182 min-Zu Road, Wuhan 430074 ...

Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao 266003, P. R. China Qingdao Key Laboratory of Thyroid, Diseases, Medical Research Center, Qingdao 266555, ...

An important control mechanism for the quality of cells and survival in the vessel wall is autophagy, which is a highly conserved self-protecting process as cellular response to stress, in which ...

The protein kinase B (PKB/AKT) family of serine/threonine kinases is involved in numerous neuromolecular signaling processes (Kandel and Hay, 1999; Franke, 2008) and has been implicated in ...