So-called diabetic cardiomyopathy may affect up to 20% of people with chronic diabetes and represents a unique target for treatment. In this interview, James Januzzi, MD, FACC, and Alison L. Bailey, ...

Treatment with AT-001, a highly selective aldose reductase inhibitor, had no significant effect on exercise capacity as measured by peak oxygen uptake (VO2) among individuals with diabetic ...

The active site of the enzyme, which contains critical metal ions like magnesium (Mg²⁺) or cobalt (Co²⁺), stabilizes the substrate and facilitates the conversion between the aldose (glucose) and ...