Renal hypoperfusion occurs as a result of reduced cardiac output, resulting in the activation of the renin–angiotensin–aldosterone system, which compensates for the hypoperfusion. However ...

Aldosterone might have a role in the progression of renal disease; therefore, van den Meiracker et al. investigated whether adding the aldosterone receptor antagonist spironolactone to renin ...

which have shown that renal patients profit enormously from interventions such as statins and blockers of the renin–angiotensin–aldosterone system, especially during the early stages of ...

By competing with aldosterone for receptor sites in distal renal tubules, spironolactone increases sodium chloride and water excretion while conserving potassium and hydrogen ions. The inhibition ...

Aldosterone antagonists (spironolactone ... New York Heart Association functional class IV symptoms, preserved renal function and a normal potassium concentration. Spironolactone was investigated ...

Aldosterone tells the kidney and other organs to retain sodium, which helps maintain the existing fluid in the body. However, when aldosterone is inappropriately high, a condition called primary ...

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It suppresses the renin-angiotensin-aldosterone system ... Postsympathectomy. Renal or hepatic impairment. Dialysis (esp. high-flux membrane). Gout. Asthma. SLE. Acute myopia.

Palatin Technologies, Inc. (NYSE American: PTN), a biopharmaceutical company developing first-in-class medicines based on ...