RNA-based therapeutics are gaining traction due to advancements in delivery technologies, despite historical challenges with ...

Most DNA molecules consist of two polymers (double-stranded) of four nucleotides that each consist of a nucleobase, the carbohydrate deoxyribose and a phosphate group, where the carbohydrate and ...

Extracellular and intracellular adenine nucleotides (ANs) act as paracrine mediators or intracellular second messengers in almost all central processes in biology and medicine. They are essential for ...

PARTITION chromatography on paper 1 has not hitherto been reported for the analysis of riboflavine, its nucleotides and derivatives. However, ‘Collidine', and a butyl alcohol-acetic acid mixture ...

Modulating purinergic signaling (encompassing pyrimidine nucleotides as well) and other nucleoside targets with small molecules is fruitful for identifying new directions for therapeutic intervention.

Specifically, NucMoMTL leverages a pre-trained language model for robust sequence embedding and utilizes deep multi-task and multi-scale learning within parameter-based orthogonal constraints to ...

Arrows indicate the magnitudes of adjustments made to mutational fitness that result in median fitness of synonymous substitutions at paired (+0.32) and unpaired (−1.13) positions identical to the ...

Here we show that pyrimidine nucleotides can also bind and inhibit its proton-conducting activity. All nucleotides bound in a pH-dependent manner, with the highest binding affinity observed for ATP, ...

Mutations in the SARS-CoV-2 genome happen when errors are made as the RNA genetic material is copied. The SARS-CoV-2 genome is made of an RNA chain consisting of four units called nucleotides, known ...

In "Everything Everywhere All At Once," nihilism drives Alphaverse character Jobu Tupaki to the brink. Credit: A24 There's no simple way to sum up the Oscar-winning Everything Everywhere All At Once.