Frontiers14 天
The mARS complex: a critical mediator of immune regulation and homeostasis
Over the course of evolution, many proteins have undergone adaptive structural changes to meet the increasing homeostatic regulatory demands of multicellularity. Aminoacyl tRNA synthetases (aaRS), ...
The Scientist1 个月
Targeting the Worm Microbiome to Combat Filariasis
Lymphatic filariasis, a devastating parasitic disease transmitted by mosquitoes, affects more than 110 million people worldwide. 1 People who suffer from the infection experience extremely painful ...
C&EN1 个月
Nonuniform Chiralization of Metal–Organic Frameworks Using Imine Chemistry
Laboratory of Molecular Simulation (LSMO), Institut des Sciences et Ingénierie Chimiques, Valais École Polytechnique Fédérale de Lausanne (EPFL), Rue de l’Industrie 17, Sion, Valais CH-1951, ...
eLife3 年
Edge-strand of BepA interacts with immature LptD on the β-barrel assembly machine to ...
The outer membrane (OM) of Gram-negative bacteria functions as a selective permeability barrier. Escherichia coli periplasmic Zn-metallopeptidase BepA contributes to the maintenance of OM integrity ...
eLife11 年
Mechanism of chiral proofreading during translation of the genetic code
The crystal structure of dimeric D-aminoacyl-tRNA deacylase (DTD) from Plasmodium falciparum in complex with a substrate-mimicking analog shows how it uses an invariant ‘cross-subunit’ Gly-cisPro ...