Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

Mechanisms were explored via LC‒MS/MS, coimmunoprecipitation, laser microirradiation, immunofluorescence, the homologous recombination (HR) or non-homologous end joining (NHEJ) reporter system, in ...

Most human somatic cells have limited or no telomerase activity, resulting in telomere erosion with age. Telomere attrition is one of the most direct and predictable pathways to senescence, as ...

Scientists are looking for answers about how these confounding trips, known as metastases, occur throughout the human body Illustration of a human cancer cell Amber Dance, Knowable Magazine Back ...

Department of Chemistry, Green Chemistry & Materials Modelling Laboratory, Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi 127788, United Arab Emirates Department of Chemistry ...

Faculty for Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Aapistie 7, 90220 Oulu, Finland ...

“Oct4 is so powerful, it's like a bulldozer. It's opening chromatin like crazy,” said Schöler, who hypothesized that overexpression of the transcription factor in somatic cells that don't normally ...

These lobules are connected to small ducts (tubes) that connect with larger ducts to form the common hepatic duct. The common hepatic duct transports the bile made by the liver cells to the ...

Orbai talks about how to recognize common autoimmune disease symptoms and when you should see a doctor. Autoimmune disease happens when the body’s natural defense system can’t tell the difference ...

2016; Luong et al., 2020). Follicles are complex aggregations comprising germ cells and various somatic cells, and the regulation of folliculogenesis not only relies on the complex signal ...

Germ-cell specification and suppression of the somatic gene expression programme might involve epigenetic modifications. Furthermore, differentiating primordial germ cells (PGCs) show global ...