President Donald Trump has ordered federal officials to scour monuments, memorials and statues to remove language he says may "inappropriately disparage Americans," as part of his efforts to fight ...

2018). The proteins include: (4) Silent information regulator 1 (SIRT1) is a deacetylase that affects the activity of various transcription factors through deacetylation, thereby directly inducing the ...

During starvation-induced autophagy, ATG2A undergoes depalmitoylation as the balance between ZDHHC11-mediated palmitoylation and APT1-mediated depalmitoylation. Inhibition of ATG2A depalmitoylation ...

自噬由多个阶段组成，启动阶段主要由 ATG1/ULK1 复合体调控，mTOR 激酶通过磷酸化 ULK1 和 ATG13 抑制自噬，而 AMPK 和 p53 信号则促进自噬。成核阶段由 VPS34—VPS15—Beclin-1 复合体驱动，该复合体有两种功能不同的形式，分别促进自噬体形成和成熟。延伸和闭合阶段由 ...

State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China ...

Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China ...

An important control mechanism for the quality of cells and survival in the vessel wall is autophagy, which is a highly conserved self-protecting process as cellular response to stress, in which ...

Adenosine triphosphate (ATP) at millimolar levels has recently been implicated in the solubilization of cellular proteins. However, the significance of this high ATP level under physiological ...

Mitophagy plays an important role in mitochondrial homeostasis. In yeast, the phosphorylation of the mitophagy receptor Atg32 by casein kinase 2 is essential for mitophagy. This phosphorylation is ...