Medically reviewed by Kashif J. Piracha, MD Armpit pain can have many causes, ranging from injuries and irritants to infections that cause swollen lymph nodes. Less commonly, the pain—referred to as ...

Painful armpit lumps are often due to a swollen axillary lymph node under the armpit. This is usually a sign that the body is fighting an infection, but it can sometimes indicate cancer.

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Lymph nodes are part of the body’s immune system. A swollen lymph node in the armpit may be a sign of a bacterial or viral infection, an injury, or a serious health condition, such as cancer.